Vaccine that lowers cholesterol offers hope of immunizing against cardiovascular disease

Posted: 19 Jun 2017 03:00 AM PDT

A vaccine to immunise people against high levels of cholesterol and the narrowing of the arteries caused by build-up of fatty material (atherosclerosis) may be possible following successful results in mice. Now, a phase I trial in patients has started to see if the findings translate to humans. The study, which is published today in the European Heart Journal [1], is the first to show that it is possible to immunise genetically modified mice with a molecule that causes the body to produce antibodies

High doses of vitamin C to improve cancer treatment passes human safety trial

Posted: 31 Mar 2017 03:00 AM PDT

Clinical trials found that it is safe to regularly infuse brain and lung cancer patients with 800 - 1000 times the daily recommended amount of vitamin C as a potential strategy to improve outcomes of standard cancer treatments. In a work presented in Cancer Cell, University of Iowa researchers also show pathways by which altered iron metabolism in cancer cells, and not normal cells, lead to increased sensitivity to cancer cell death caused by high dose vitamin C.

Vitamin D protects against colds and flu, finds major global study

Posted: 20 Feb 2017 03:00 AM PST

Vitamin D supplements protect against acute respiratory infections including colds and flu, according to a study led by Queen Mary University of London (QMUL). The study provides the most robust evidence yet that vitamin D has benefits beyond bone and muscle health, and could have major implications for public health policy, including the fortification of foods with vitamin D to tackle high levels of deficiency in the UK.

Alcohol shown to act in same way as rapid antidepressants

Posted: 29 Sep 2016 03:00 AM PDT

Can having a few drinks help people with clinical depression feel better? Yes. At least in terms of biochemistry. In a study published in the current issue of the journal Nature Communications, researchers found that alcohol produces the same neural and molecular changes as drugs that have proven to be rapidly effective antidepressants.

Component of red wine, grapes can help to reduce inflammation

Posted: 28 Sep 2016 03:00 AM PDT

A component of red wine and grapes can help control inflammation induced by a bacterial pathogen that is linked to upper respiratory tract inflammatory diseases such as asthma, chronic obstructive pulmonary diseases (COPD) and middle ear infection (otitis media), according to a study by researchers at Georgia State University. The findings, published in the online journal Scientific Reports, identify a novel mechanism that resveratrol, a compound found naturally in some plant foods such as grapes, uses to alleviate inflammation in airway disease.

Historical analysis examines sugar industry role in heart disease research

Posted: 20 Sep 2016 03:00 AM PDT

Using archival documents, a new report published online by JAMA Internal Medicine examines the sugar industry's role in coronary heart disease research and suggests the industry sponsored research to influence the scientific debate to cast doubt on the hazards of sugar and to promote dietary fat as the culprit in heart disease. Stanton A. Glantz, Ph.D., of the University of California, San Francisco, and coauthors examined internal documents from the Sugar Research Foundation (SRF), which later evolved into the Sugar Association, historical reports and other material to create a chronological case study.

Caffeine and its analogues revert memory deficits by normalizing stress responses in the brain

Posted: 31 Aug 2016 01:00 AM PDT

A study published in the journal Scientific Reports from Nature publishing group, describes the mechanism by which caffeine counteracts age-related cognitive deficits in animals. The study coordinated by Portuguese researchers from Instituto de Medicina Molecular (iMM Lisboa) and collaborators from Inserm in Lille, France, along with teams from Germany and United States,